For nearly 50 years,Sleisenger & Fordtran's Gastrointestinal and Liver Diseasehas been the go-to reference for gastroenterology and hepatology residents, fellows, physicians, and the entire GI caregiving team. Now in a fully revised 11th Edition, this two-volume masterworkbrings together the knowledge and expertise of hundreds of global experts who keep you up to date with thenewest techniques, technologies, and treatments for every clinical challenge you face in gastroenterology and hepatology. A logical organization,more than 1,100 full-color illustrations , and easy-to-use algorithms ensure that you'll quickly and easily find the information you need.

VOLUME 1 Part I Biology of the Gastrointestinal tract 1 Cellular Growth and Neoplasia, 1Ezra Burstein2 Mucosal Immunology and Inflammation, 13CIharles O. Elson and Phillip D. Smith3 The Enteric Microbiota, 24Eugene B. Chang and Purna Kashyap4 Gut Sensory Transduction, 34Diego V. Bohórquez and Rodger A. Liddle

Part II Nutrition in Gastroenterology 5 Nutritional Principles and Assessment of the Gastroenterology Patient, 52Joel B. Mason6 Nutritional Management, 74Angela K. Pham and Stephen A. McClave7 Obesity, 92Rekha B. Kumar and Louis J. Aronne8 Surgical and Endoscopic Treatment of Obesity, 101Shelby Sullivan, Steven A. Edmundowicz, and John Magaña Morton9 Feeding and Eating Disorders, 117Debra K. Katzman and Mark L. Norris10 Food Allergies, 133J. Andrew Bird

Part III Symptoms, Signs, and Biopsychosocial Issues 11 Acute Abdominal Pain, 144Frederick H. Millham12 Chronic Abdominal Pain, 158Joseph C. Yarze and Lawrence S. Friedman13 Symptoms of Esophageal Disease, 168Kenneth R. DeVault14 Dyspepsia,177Jan Tack15 Nausea and Vomiting, 191Arvind Rengarajan and C. Prakash Gyawali16 Diarrhea, 204Lawrence R. Schiller and Joseph H. Sellin17 Intestinal Gas,224Fernando Azpiroz18 Fecal Incontinence,232Satish S.C. Rao19 Constipation,250Johanna C. Iturrino and Anthony J. Lembo20 Gastrointestinal Bleeding, 276Thomas J. Savides and Dennis M. Jensen21 Jaundice, 313Steven D. Lidofsky22 Biopsychosocial Issues in Gastroenterology,324Douglas A. Drossman and Laurie Keefer23 Factitious Gastrointestinal Disease,340John S. Fordtran and Anahit A. Zeynalyan

Part IV topics Involving Multiple Organs 24 Oral Diseases and Oral Manifestations of Gastrointestinal and Liver Diseases, 350Kimberly L. Pham and Ginat W. Mirowski25 Cutaneous Manifestations of Gastrointestinal and Liver Diseases, 359Lawrence A. Mark26 Diverticula of the Pharynx, Esophagus, Stomach, and Small Intestine, 372Kerry B. Dunbar and D. Rohan Jeyarajah27 Abdominal Hernias and Gastric Volvulus, 381D. Rohan Jeyarajah and Kerry B. Dunbar28 Foreign Bodies, Bezoars, and Caustic Ingestions, 399Patrick R. Pfau and Mark Benson29 Abdominal Abscesses and Gastrointestinal Fistulas, 411Gregory dePrisco, Scott Celinski, and Cedric W. Spak30 Eosinophilic Disorders of the Gastrointestinal Tract, 424Marc E. Rothenberg and Vidhya Kunnathur31 Protein-Losing Gastroenteropathy, 435David A. Greenwald32 Gastrointestinal Lymphomas, 442Praveen Ramakrishnan Geethakumari and Syed Mujtaba Rizvi33 Gastrointestinal Stromal Tumors, 458Margaret von Mehren34 Neuroendocrine Tumors, 472Jonathan R. Strosberg and Taymeyah Al-Toubah35 Gastrointestinal Consequences of Infection with Human Immunodeficiency Virus, 498C. Mel Wilcox36 Gastrointestinal and Hepatic Complications of Solid Organ and Hematopoietic Cell Transplantation, 510Anne M. Larson, Rachel B. Issaka, and David M. Hockenbery37 Gastrointestinal and Hepatic Manifestations of Systemic Diseases, 532Frederick Weber38 Vascular Lesions of the Gastrointestinal Tract, 561Joann Kwah and Lawrence J. Brandt39 Surgical Peritonitis and Other Diseases of the Peritoneum, Mesentery, Omentum, and Diaphragm, 580Jeffrey B. Matthews and Kiran Turaga40 Gastrointestinal and Hepatic Disorders in the Pregnant Patient, 593Shilpa Mehra and John F. Reinus41 Acute and Chronic Gastrointestinal Side Effects of Radiation Therapy, 606Jarred P. Tanksley, Christopher G. Willett, Brian G. Czito, and Manisha Palta42 Preparation for and Complications of Gastrointestinal Endoscopy, 619Aravind Sugumar and John J. Vargo II

Part V Esophagus 43 Anatomy, Histology, Embryology, and Developmental Anomalies of the Esophagus,627Ryan D. Madanick and Vishal Kaila44 Esophageal Neuromuscular Function and Motility Disorders, 638John E. Pandolfino and Peter J. Kahrilas45 Esophageal Disorders Caused by Medications, Trauma, and Infection, 661David A. Katzka46 Gastroesophageal Reflux Disease, 670Joel E. Richter and Michael F. Vaezi47 Barrett Esophagus, 691 Stuart Jon Spechler and Rhonda F. Souza48 Esophageal Tumors, 700Hazem Hammad and Sachin Wani

Part VI Stomach and Duodenum 49 Anatomy, Histology and Developmental Anomalies of the Stomach and Duodenum, 720M. Gaith Semrin50 Gastric Neuromuscular Function and Neuromuscular Disorders, 735Kenneth L. Koch51 Gastric Secretion,764 Mitchell L. Schubert and Jonathan D. Kaunitz52 Gastritis and Gastropathy, 781Mark Feldman, Pamela J. Jensen, and Colin W. Howden53 Peptic Ulcer Disease, 806Francis K.L. Chan and James Y.W. Lau54 Adenocarcinoma of the Stomach and Other Gastric Tumors, 820Michael Quante and Jan Bornschein

Part VII Pancreas 55 Anatomy, Histology, Embryology, and Developmental Anomalies of the Pancreas, 842Megha S. Mehta, Bradley A. Barth, and Sohail Z. Husain56 Pancreatic Secretion, 853Stephen J. Pandol57 Genetic Disorders of the Pancreas and Pancreatic Disorders in Childhood, 862David C. Whitcomb and Mark E. Lowe58 Acute Pancreatitis, 893Santhi Swaroop Vege59 Chronic Pancreatitis, 917Chris E. Forsmark60 Pancreatic Cancer, Cystic Pancreatic Neoplasms, and Other Nonendocrine Pancreatic Tumors, 947Bijal Modi and G. Thomas Shires61 Endoscopic Treatment of Pancreatic Disease, 965Ryan Law and Todd H. Baron

Part VIII Biliary tract 62 Anatomy, Histology, Embryology, Developmental Anomalies, and Pediatric Disorders of the Biliary Tract, 973Frederick J. Suchy and Cara L. Mack63 Biliary Tract Motor Function and Dysfunction, 995B. Joseph Elmunzer and Grace H. Elta64 Bile Secretion and the Enterohepatic Circulation, 1001Peter Fickert and Paul A. Dawson65 Gallstone Disease, 1016David Q.-H. Wang and Nezam H. Afdhal66 Treatment of Gallstone Disease, 1047Robert E. Glasgow67 Acalculous Biliary Pain, Acute Acalculous Cholecystitis, Cholesterolosis, Adenomyomatosis, and Gallbladder Polyps, 1064Karin L. Andersson and Lawrence S. Friedman68 Primary and Secondary Sclerosing Cholangitis, 1077Cynthia Levy and Christopher L. Bowlus69 Tumors of the Bile Ducts, Gallbladder, and Ampulla, 1096Sumera H. Rizvi and Gregory J. Gores70 Endoscopic and Radiologic Treatment of Biliary Disease, 1113Theodore W. James and Todd H. Baron

VOLUME 2

Part IX Liver 71 Embryology, Anatomy, Histology, and Developmental Anomalies of the Liver,1129Ricard Masia and Joseph Misdraji72 Liver Physiology and Energy Metabolism, 1135 Namita Roy-Chowdhury and Jayanta Roy-Chowdhury73 Liver Chemistry and Function Tests, 1154Daniel S. Pratt74 Overview of Cirrhosis, 1164Patrick S. Kamath and Vijay H. Shah75 Hemochromatosis, 1172Bruce R. Bacon and Robert E. Fleming76 Wilson Disease, 1180Eve A. Roberts77 Other Inherited Metabolic Disorders of the Liver, 1189James E. Squires and William F. Balistreri78 Hepatitis A, 1210Maria H. Sjogren and Joseph G. Cheatham79 Hepatitis B, 1216Harry L.A. Janssen and Scott Fung80 Hepatitis C, 1243Jacinta A. Holmes and Raymond T. Chung81 Hepatitis D, 1283Marc G. Ghany82 Hepatitis E, 1292Rakesh Aggarwal83 Hepatitis Caused by Other Viruses, 1298Jordan J. Feld84 Bacterial, Parasitic, and Fungal Infections of the Liver, Including Liver Abscesses, 1303Arthur Y. Kim and Raymond T. Chung85 Vascular Diseases of the Liver, 1321Filipe Gaio Nery and Dominique Charles Valla86 Alcohol-Associated Liver Disease, 1336Gyongyi Szabo and Craig J. McClain87 Nonalcoholic Fatty Liver Disease, 1354Dawn M. Torres and Stephen A. Harrison88 Liver Disease Caused by Drugs, 1367Shivakumar Chitturi, Narci C. Teoh, and Geoffrey C. Farrell89 Liver Disease Caused by Anesthetics, Chemicals, Toxins, and Herbal and Dietary Supplements, 1399James H. Lewis90 Autoimmune Hepatitis, 1415Albert J. Czaja91 Primary Biliary Cholangitis, 1433John E. Eaton and Keith D. Lindor92 Portal Hypertension and Variceal Bleeding, 1443Vijay H. Shah and Patrick S. Kamath93 Ascites and Spontaneous Bacterial Peritonitis, 1471Elsa Solà and Pere Ginès94 Hepatic Encephalopathy, Hepatorenal Syndrome, Hepatopulmonary Syndrome, and Other Systemic Complications of Liver Disease, 1486Shivang S. Mehta and Michael B. Fallon95 Acute Liver Failure, 1499John O'Grady and William Bernal96 Hepatic Tumors and Cysts, 1509Adrian M. Di Bisceglie and Alex S. Befeler97 Liver Transplantation, 1533Andres F. Carrion and Paul Martin

Part X Small and Large Intestine 98 Anatomy, Histology, Embryology, and Developmental Anomalies of the Small and Large Intestine, 1551Lee M. Bass and Barry K. Wershil99 Small Intestinal Motor and Sensory Function and Dysfunction, 1580Christopher K. Rayner and Patrick A. Hughes100 Colonic Motor and Sensory Function and Dysfunction, 1595Philip G. Dinning, Marcello Costa, and Simon J.H. Brookes101 Intestinal Electrolyte Absorption and Secretion, 1611Mrinalini C. Rao and Jayashree Sarathy102 Digestion and Absorption of Carbohydrate, Protein, and Fat, 1636Yangzom D. Bhutia and Vadivel Ganapathy103 Digestion and Absorption of Micronutrients, 1657Michelle Pearlman and Jaime Almandoz104 Maldigestion and Malabsorption, 1677Christoph Höegenauer and Heinz F. Hammer105 Small Intestinal Bacterial Overgrowth, 1711Brian E. Lacy and John K. DiBaise106 Short Bowel Syndrome, 1720Alan L. Buchman107 Celiac Disease, 1736Benjamin Lebwohl and Peter H.R. Green108 Tropical Diarrhea and Malabsorption, 1756Balakrishnan S. Ramakrishna109 Whipple Disease, 1769Matthias Maiwald, Axel von Herbay, and David A. Relman110 Infectious Enteritis and Proctocolitis, 1779Joanna M.P. Melia and Cynthia L. Sears111 Food Poisoning, 1810Jennifer Katz112 Antibiotic-Associated Diarrhea and Clostridioides difficile Infection, 1818Ciarán P. Kelly and Sahil Khanna113 Intestinal Protozoa, 1834Christopher D. Huston114 Intestinal Worms, 1847M. Nedim Ince and David E. Elliott115 Epidemiology, Pathogenesis, and Diagnosis of Inflammatory Bowel Diseases, 1868Gilaad G. Kaplan and Siew C. Ng116 Management of Inflammatory Bowel Diseases, 1898Ashwin N. Ananthakrishnan and Miguel D. Regueiro117 Ileostomies, Colostomies, Pouches, and Anastomoses, 1930Ahsan Raza and Farshid Araghizadeh118 Intestinal Ischemia, 1944Paul Feuerstadt and Lawrence J. Brandt119 Intestinal Ulcerations, 1970Blair Lewis and Daniel S. Mishkin120 Appendicitis,1983Martin Daniel Rosenthal and George S. Sarosi, Jr. 121 Diverticular Disease of the Colon, 1993Taft P. Bhuket and Neil H. Stollman122 Irritable Bowel Syndrome, 2008Alexander C. Ford and Nicholas J. Talley123 Intestinal Obstruction, 2021William Conan Mustain and Richard H. Turnage124 Ileus and Pseudo-Obstruction Syndromes, 2039Adil E. Bharucha and David O. Prichard125 Tumors of the Small Intestine, 2059Boris Blechacz and Robert Scott Bresalier126 Colonic Polyps and Polyposis Syndromes, 2076John J. Garber and Daniel C. Chung127 John J. Garber and Daniel C. Chung Colorectal Cancer, 2108Robert Scott Bresalier128 Other Diseases of the Colon, 2153Darrell S. Pardi and Thomas G. Cotter129 Anal Diseases, 2169J. Marcus Downs and Benjamin Kulow

Part XI additional treatments for Patients with Gastrointestinal and Liver Disease 130 Probiotics, 2187Eamonn M.M. Quigley131 Complementary, Alternative, and Integrative Medicine, 2192Jill K. Deutsch and David J. Hass132 Palliative Care Medicine in Patients with Advanced Gastrointestinal and Hepatic Disease, 2206Vyjeyanthi S. Periyakoil, Nielsen Fernandez-Becker, and Sarah E. Streett