Epigenetic Cancer Therapy, Second Edition provides a comprehensive discussion of healthy and aberrant epigenetic biology, along with new discoveries to improve our understanding of cancer epigenetics and therapeutics. The book encompasses large-scale intergovernmental initiatives, as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. Since the publication of the first edition of this book, the field of epigenetics has undergone significant change. New epigenetic therapies have been designed and approved for clinical use.

Our knowledge of the plasticity of the epigenome in cancer and disease has expanded dramatically, with increasing evidence linking pollution to epigenetic changes in cancer development. This second edition has been fully updated to address these changes, along with promising therapeutic programs such as CRISPR/Cas9 mediated approaches, CAR-T based therapies, epigenetic priming, histone modifications, and similar, transformative advances across synthetic biology and cellular engineering.

Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, thus demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs Provides a fully updated resource on new topics, including the epitranscriptome, oncohistones, single cell analysis, epigenetic priming, CRISPR therapy, CAR-T therapy, and epigenetics and pollution Features chapter contributions from leading experts in the field

1. Introduction

Part 1: Introduction and Key Concepts 2. DNA Methylation and Hydroxymethylation in Cancer 3. Writers, Readers, and Erasers of Epigenetic Marks 4. Oncohistones 5. MicroRNAs, epi-miRNAs and Cancer 6. Long Noncoding RNAs and Cancer 7. The Epitranscriptome 8. Mining the Epigenetic Landscape: Surface Mining or Deep Underground - Alecsandar Milosavljevic 9: Epigenetics Clocks: Concepts for Carcinogenesis10: Environmental Pollution Epigenetics and Cancer

Part 2: Epigenetics and Cancer 11. Development of Epigenetic Targeted Therapies in Hematological Malignancies: From Serendipity to Synthetic Lethality 12. Epigenetic Therapy in Lung Cancer 13. Breast Cancer Epigenetics 14. Therapeutic Applications of the Prostate Cancer Epigenome 15. Neuroblastoma

Part 3: Targeting Aberrant Epigenetics 16. Nutritional Epigenetic Regulators in the Field of Cancer: New Avenues for Chemopreventive Approaches - 17. Emerging Epigenetic Therapies- Lysine Methyltransferase/PRC Complex Inhibitors 18. Inhibitors of Jumonji C-Domain Histone Demethylases 19. Emerging Epigenetic Therapies: Lysine Acetyltransferase Inhibitors 20: Histone Deacetylases 21. Emerging Epigenetic Therapies

Part 4: Issues to Overcome/Areas of Concern 22. Genetic Intratumoral Heterogeneity 23. Challenges for single cell epigenetic analysis 24. Epigenetics Underpinning DNA Damage Repair 25. Epigenetics of Cisplatin Resistance 26. Therapeutically Targeting Epigenetic Regulation of Cancer Stem Cells

Part 5: Future Directions: Translation to the Clinic 27. Personalized Epigenetic Therapy-Chemosensitivity Testing 28. Personalized Therapy-Epigenetic Profiling as Predictors of Prognosis and Response 29. Epigenetic Priming - Fact or Fallacy 30. CRISPR and epigenetics 31. Epigenetics and CAR-T