The astonishing true story of how Catherine the Great joined forces with a Quaker doctor from Essex to spearhead one of the first global public health campaigns.

A TIMES BEST BOOK OF 2022 SO FAR

Shortlisted for the Pushkin House Book Prize 2022

‘Sparkling history…with a fairytale atmosphere of sleigh rides, royal palaces and heroic risk-taking’ The Times

A killer virus…an all-powerful Empress…an encounter cloaked in secrecy…the astonishing true story.

Within living memory, smallpox was a dreaded disease. Over human history it has killed untold millions. Back in the eighteenth century, as epidemics swept Europe, the first rumours emerged of an effective treatment: a mysterious method called inoculation.

But a key problem remained: convincing people to accept the preventative remedy, the forerunner of vaccination. Arguments raged over risks and benefits, and public resistance ran high. As smallpox ravaged her empire and threatened her court, Catherine the Great took the momentous decision to summon the Quaker physician Thomas Dimsdale to St Petersburg to carry out a secret mission that would transform both their lives. Lucy Ward expertly unveils the extraordinary story of Enlightenment ideals, female leadership and the fight to promote science over superstition.

‘A rich and wonderfully urgent work of history’ Tristram Hunt

'Ward ably contextualises the event within the intellectual currents of the era... Astute.'

‘This is a remarkable and fascinating story of scientific discovery, breakthrough medicine and inspirational female leadership by Catherine the Great. The revelations in this book resonate with today’s battle against Covid-19. Lucy Ward has undertaken brilliant detective work… This is a must-read book.’

‘Informative, enthusiastically written and based on thorough research.’

‘A fascinating, deep dive into a neglected topic in the history of vaccines, with many lessons for the prevention of viruses today. Lucy Ward blends history and personality to shed light on a story that has been overlooked in favour of Jenner and his milkmaid.’

‘A tale of multiple and intertwining themes – private and public health, public administration, and the politics of Empires… Although the book is about things that happened over 250 years ago, the hopes and fears of the people facing those difficult choices resonate with our own times.’

‘An entertaining account… Brimming with vivid historical details, this is a memorable account of a medical and social breakthrough.’

‘Timely and engaging…the unlikely and remarkable story of how an English doctor, Thomas Dimsdale, and Catherine the Great, the Empress of Russia, showed great personal courage and took serious personal risks to promote inoculation against smallpox using a method that had originated in Asia. The success of these early efforts led directly to the first vaccine by Jenner, and over the next two centuries saved millions of lives that would have been lost to many different diseases, culminating in the recent vaccines against Covid-19. A truly fascinating book that reads like a thriller.’

‘It’s hard to imagine a better-timed book than this one'

‘Packed with political intrigue and scientific insight, this is a fascinating narrative revealing how early inoculation pioneers overcame superstition, prejudice and misinformation. Move forward more than two centuries and the parallels with the current Covid-19 pandemic are incredible!’

‘Timely and engaging… A truly fascinating book that reads like a thriller.’

‘Women’s role in driving forward key scientific discoveries has too often gone unrecognised. The Empress and the English Doctor honours Catherine the Great’s pioneering scientific journey, demonstrating her personal bravery, her exacting insight and her resolve to protect others against smallpox. This thrilling and important story offers an insight into the determination, tenacity and grit needed to work in science, even today!’

‘A rich and wonderfully urgent work of history which engagingly recounts one of the greatest moments in modern science and public health: a story of Enlightenment conviction, Court intrigue, Anglo-Russian relations, and timeless, personal bravery. An expertly recounted eighteenth-century tale of political leadership and medical progress with obvious insights for today.’

‘A fascinating and beautifully told story about courageous vaccination pioneers.’

‘In this fluent and enlightening account of the fight to eradicate the terrifying scourge of smallpox, Ward deftly describes how an English Quaker doctor, Thomas Dimsdale, played a crucial role as a pioneer of the new technique of inoculation… The Empress and the English Doctor is a gripping read and all the more timely and extraordinary for having been written in the midst of the Covid pandemic.’

‘The scepticism and hesitancy about COVID-19 vaccines make Ward’s eminently readable history feel timely as she expertly examines the intersection of medicine and politics.’

‘Timely… The author demonstrates beautifully how London has historically led on the science with first “inoculation” and then “vaccination” – indeed, longer than most people realise.’

‘This is a wonderful book. It tells the story of the greatest medical discovery before Pasteur, inoculation against smallpox, through the life of a Quaker doctor, Thomas Dimsdale, and his journey to Russia to treat Catherine the Great… It’s a long time since I’ve read a history book as beautifully constructed as this – it’s a remarkable achievement.’

‘By 1980, the global smallpox vaccination campaign had resulted in the complete eradication of the deadly disease. Ward’s captivating and informative book relates events that took place two centuries earlier and laid the foundation of this unique achievement.’

‘Lively and informative.’

‘So meticulously researched, well-paced and finely written is this tale of medical drama and royal daring that one quickly forgets that it is Lucy Ward’s first book. Her story is a remarkable one, full of contemporary resonance, but fascinating in its own right… a real page-turner.’

‘Lucy Ward has zoomed in on one of the more dramatic episodes in that dramatic century… vivid.’

‘Entertaining and well-researched.’

‘[A] sparkling history book with a fairytale atmosphere of sleigh rides, royal palaces and heroic risk-taking… This is exactly the book we need to read at the moment.’

‘An enthralling tale of two remarkable personalities who risked all for the benefit of mankind, and of a struggle between medical science and human instinct that could not be more relevant today.’

‘Offers unforced parallels with our present … At the heart of this learned, erudite book, full of rich and legible scientific detail, is the extraordinary, and extraordinarily moving, dynamic between the Empress and Dimsdale … [a] rather thrilling account.’

‘Mirroring so many of the vaccination issues of our modern age, as well as those of bodily autonomy, feminism, and power…a must-read.’

‘A deft and captivating chronicle.’

‘This gripping account of her deep friendship with an English doctor – and their battle to save the Russian people from the scourge of smallpox – shows [Catherine the Great] in an entirely different light.’

'[a] gripping story of Enlightenment ideals, female leadership, and the fight to promote science over superstition.'

‘This is a fascinating and meticulously researched book with the excitement of a thriller. It’s a remarkable story of female leadership and personal courage. Lucy Ward uses her brilliance as a narrator combined with her insight as a former Lobby journalist to bring to life one of history’s most powerful women who really did “follow the science”.’

‘A combination of arcane detail and the high colour of a period drama.’

‘An extraordinary and fascinating story’

‘A poignant tale, expertly researched and beautifully written.’