Sherlock's Diseases Of The Liver & Biliary System

Item Information
Item#: 9781119237549
Edition 13
Author Dooley Et Al (Eds)
Cover Hardback
On Hand 0
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A new, fully updated edition of the world&s most famous book on liver diseases-with updating of all areas and inclusion of new specific topics, by internationally renowned specialists This
and new edition of the classic book on hepatology provides a concise, clearly presented and well-structured review across the whole spectrum of hepatobiliary diseases by some of the world&s leading hepatologists and hepatobiliary specialists. Where many other hepatology textbooks provide detailed accounts of basic science and clinical management, Sherlock's Diseases of the Liver and Biliary System, 13th Edition takes a different approach. Concentrating on the clinical decisions to be taken and the relevant supporting data, it is written and edited to maintain Sheila Sherlock's unique approach, in particular the clarity and layout of the text, and the explanatory figures and tables. The book is thus concise, highly accessible, and generously illustrated with over 700 attractive color figures. There is a pithy approach to each disease based both on evidence and on the authors& experience, the hallmark of this book. Based on these elements, the 12th edition was awarded first prize in the 2012 British Medical Association Book Awards in the Internal Medicine category.Sherlock's Diseases of the Liver and Biliary System begins by introducing the anatomy and function of the liver to readers, continuing then with in-depth coverage of liver biopsy techniques and interpretation, and fi
ogenesis and its assessment. There are then chapters on all aspects of liver and biliary disease including acute liver failure, cirrhosis, portal hypertension, hepatic encephalopathy, ascites, hepatitis B and C, alcohol and the liver, non-alcoholic fatty liver disease, drug related liver reactions, cholestatic, autoimmune and genetic liver diseases, benign and malignant tumours and not least liver transplantation. There are also chapters on the liver in pregnancy, in the neonate, infancy and childhood, in systemic diseases and in infections. This new edition also features four new individual chapters focusing on coagulation, non-invasive assessment of fi
osis and cirrhosis; vascular diseases of the liver and portal vein thrombosis, and nutrition in liver disease. Digital downloads of the figures from this edition are offered on a companion website.Internationally recognized and loved, world-renowned hepatology book, first published in 1955Takes a one-of-a-kind, clinical approach maintaining Sheila Sherlock&s clarity and legacy of presentationFull colour throughout with 700 illustrative figuresWide faculty of international contributorsSherlock's Diseases of the Liver and Biliary System, 13th Edition is an ideal primer in hepatology for students and trainees in hepatology and gastroenterology, and a valuable resource for all specialist gastroenterologists and hepatologists, paediatricians, pathologists, radiologists, general physicians and specialist nurses. 

Table of Contents
List of Contributors xiPreface to the Thirteenth Edition xvPreface to the First Edition xvi1. Anatomy and Function 1<
/> Jay H. LefkowitchDevelopment of the liver and bile ducts 1Anatomy of the liver 1Functional liver anatomy: sectors and segments 3Anatomical abnormalities of the liver 3Anatomy of the biliary tract 4Surface marking 5Methods of examination 6Microanatomy of the liver 7Hepatic ultrastructure (electron microscopy) and organelle functions 9Functional heterogeneity of the liver 13Dynamics of the hepatic microenvironment in physiology and disease 14 Hepatocyte death and regeneration 15 References 162 Liver Function in Health and Disease: Clinical Application of Liver Tests 20<
/> George Mells and Graeme AlexanderBilirubin metabolism 21Bile acids 23Lipid and lipoprotein metabolism 26Amino acid metabolism 28Plasma proteins 29Carbohydrate metabolism 31Markers of hepatocellular injury: the serum transaminases 32Markers of cholestasis: alkaline phosphatase (ALP) and gamma‐glutamyl transferase (GGT) 33Haematology in liver disease 34Effects of ageing on the liver 35References 363 Biopsy of the Liver 39<
/> David Patch and Tu Vinh LuongSelection and preparation of the patient 39Techniques 40Risks and complications 43Sampling variability  45Naked‐eye appearances 46Preparation of the specimen 46Interpretation: a stepwise diagnostic approach 46Indications 48Special methods 49References 504 Coagulation in Cirrhosis 53<
/> Nicolas M. Intagliata and Stephen H. Caldwell   Introduction  53Normal coagulation pathways: a hepatologist&s perspective 54The coagulation system in cirrhosis 56Bleeding and thrombosis in cirrhosis 57Clinical laboratory tests of the coagulation system in cirrhosis 58Conclusion 60References 605 Acute Liver Failure 62<
/> Shannan R. Tujios and William M. LeeDefinition 62Epidemiology and aetiologies  63Clinical features 66Initial investigations 67Complications and management of acute liver failure 68Specific therapies 73Prognosis 75Liver transplantation 76Conclusion 78References 786 Hepatic Fi
ogenesis 82<
/> Meena B. Bansal and Scott L. FriedmanIntroduction 82Natural history of hepatic fi
osis 82Cellular and molecular features of hepatic fi
osis 83Clinical aspects of hepatic fi
osis 89Emerging antifi
otic targets and strategies 89References 907 Non‐invasive Assessment of Fi
osis and Cirrhosis 93<
/> Avik Majumdar and Massimo PinzaniIntroduction 93The use of invasive and non‐invasive tests 93Non‐invasive tests: specifics 95Conclusions 102References 1038 Hepatic Cirrhosis 107<
/> P. Aiden McCormick and Rajiv JalanDefinition 107Causes of cirrhosis 107Anatomical diagnosis 108Reversible cirrhosis 110Clinical cirrhosis: compensated versusdecompensated 110Prognosis (Child&Pugh score, MELD, UKELD) 111Clinical and pathological associations 112Management 119Acute‐on‐chronic liver failure 120References 1239 Ascites 127<
/> Guadalupe Garcia‐TsaoMechanisms of ascites formation 127Clinical features 130Differential diagnosis 132Spontaneous bacterial peritonitis 132Treatment of cirrhotic ascites 134Hyponatraemia 138Refractory ascites 139Hepatorenal syndrome 141Prognosis 144References 14510 Hepatic Encephalopathy in Patients with Cirrhosis 151<
/> Marsha Y. MorganClinical Features 151Classification 153Prevalence and consequences 154Diagnosis 154Diagnostic comorbidities, confounders, and alternatives 160Pathogenesis 161Management 167Prevention 174References 17411 Portal Hypertension in Cirrhosis 180<
/> Jaime Bosch and Annalisa BerzigottiIntroduction 180Pathophysiology and rational basis of therapy 185Evaluation and diagnosis  188Natural history and prognosis 194Management 196Treatment of portal hypertension according to clinical scenarios 200References 20512 Vascular Disorders of the Liver and Extrahepatic Portal Hypertension 209<
/> Dominique‐Charles VallaHepatic artery occlusion 209Aneurysms of the hepatic artery 210Hepatic arterioportal fistula 211Hepatic vascular malformations in hereditary haemorrhagic telangiectasia 212Congenital portosystemic shunts & Abernethy malformation  213Budd&Chiari syndrome & hepatic venous outflow tract obstruction 214Extrahepatic portal vein obstruction & portal vein thrombosis and portal cavernoma in the absence of cirrhosis 217Portal vein thrombosis in patients with cirrhosis 220Idiopathic non‐cirrhotic intrahepatic portal hypertension 221Hypoxic hepatitis 223Congestive cardiac hepatopathy 223Non‐obstructive sinusoidal dilation (NOSD) and peliosis 225References 22613 Jaundice and Cholestasis 231<
/> Peter L. M. JansenIntroduction  231Mechanics of bile formation 233Syndrome of cholestasis 238Causes of isolated hyperbilirubinaemia 239Causes of cholestatic and hepatocellular jaundice 242Consequences of cholestasis and their  management 244Investigation of the jaundiced patient 247Decisions to be made in the jaundiced patient Management of cholestatic disorders 251References 25114 Gallstones and Benign Biliary Disease 256<
/> James S. Dooley, Kurinchi S. Gurusamy, and Brian R. DavidsonIntroduction  256Imaging the gallbladder and biliary tract 256Gallstones 259Symptoms and complications of gallstones 264Cholecystectomy 266Complicated acute gallbladder disease 268Percutaneous cholecystostomy 269Asymptomatic gallbladder stones 269Non‐surgical treatment of gallstones in the gallbladder 269  Common bile duct stones 270 Acute gallstone pancreatitis 272 Large common duct stones 272 Mirizzi syndrome 273Intrahepatic gallstones 274Haemobilia 274Functional gallbladder and sphincter of Oddi disorders 274Other gallbladder pathologies 276Relationships to malignant change 279Benign biliary strictures 279Anastomotic strictures following biliary surgery 282IgG4‐related sclerosing cholangitis 283Chronic pancreatitis 283References 28415 Malignant Biliary Diseases 294<
/> Rahul S. Koti and John BridgewaterCarcinoma of the gallbladder  294Carcinoma of the bile duct (cholangiocarcinoma) 296Other biliary malignancies 301 Metastases at the hilum 301Ampullary and periampullary carcinomas  301Conclusion 305References 30516 Fi
opolycystic Liver Diseases and Congenital Biliary Abnormalities 308<
/> Nedim Hadić and Mario StrazzaboscoOverview 308Polycystic liver disease 309Fi
opolycystic diseases 313Autosomal recessive polycystic kidney disease 314Congenital hepatic fi
osis 314Caroli disease 316Microhamartomas (von Meyenberg complexes) Choledochal cysts 318Solitary non‐parasitic liver cyst 320Congenital anomalies of the biliary tract 321References 32417 Primary Biliary Cholangitis 328<
/> David E. J. JonesClinical features 328Diagnosis 329Epidemiology 333Aetiology and pathogenesis 334Management 335Prognosis 337References 33818 Sclerosing Cholangitis 341<
/> Tom Hemming Karlsen and Kirsten Muri BobergIntroduction  341Primary sclerosing cholangitis 341Secondary sclerosing cholangitis 350Sclerosing cholangitis in systemic inflammatorydiseases 351References 35119 Autoimmune Hepatitis and Overlap Syndromes 355<
/> Ashnila Janmohamed and Gideon M. HirschfieldIntroduction  355Disease overview  356Biological determinants of disease 357Disease presentation 359Laboratory features 361Imaging 363Liver biopsy and histological features 363Differential diagnosis 365Diagnostic dilemmas 366Making a diagnosis in practice 367Management strategies 368Pretreatment and on‐treatment considerations 371Treatment challenges and alternative agents 371Pregnancy and autoimmune hepatitis 372The elderly and autoimmune hepatitis 372Childhood‐onset autoimmune hepatitis 373Autoimmune hepatitis and liver transplantation 373Overlap syndromes 374Conclusion 377References 37720 Enterically Transmitted Viral Hepatitis: Hepatitis A and Hepatitis E 380<
/> Rinjal D. Brahmbhatt and Anna S. F. LokGeneral features of enterically transmitted viral hepatitis 380Hepatitis A virus 385Hepatitis E virus 389References 39121 Hepatitis B 395<
/> Anna S. F. LokIntroduction 395Hepatitis B virus 395Immune response and mechanisms of hepatic injury 398Epidemiology 399Prevention 400Diagnosis 402Clinical manifestations 404Natural history 405Treatment 408HBV and HCV coinfection 414HBV and HDV coinfection 414HBV and HIV coinfection 414References 41522 Hepatitis D 421<
/> Patrizia Farci and Grazia Anna NiroHistory 421Hepatitis D virus 421Epidemiology 422Pathogenesis 425Modes of infection and clinical course 425Diagnosis 428Treatment 429Prevention 432References 43223 Hepatitis C 436<
/> Geoffrey DusheikoIntroduction 436Epidemiology 436Virology 438Pathology and pathogenesis 439Diagnostic tests for hepatitis C 440Acute hepatitis C 441Chronic hepatitis C 441References 45924 Drug‐Induced Liver Injury 468<
/> Frank W. DiPaola and Robert J. FontanaIntroduction 468Epidemiology 468Complications of DILI 469Classification of hepatotoxicity 469Drug metabolism and pharmacokinetics 469Hepatic drug metabolism 471Molecular mechanisms in drug‐induced liver injury 472Non‐genetic risk factors for DILI 473Diagnosis of DILI 474Medical management 478Pharmacogenetic risk factors 478Potential immunological mechanisms in idiosyncratic DILI 479Liver injury from specific drugs 479References 48625 Alcohol and the Liver 494<
/> Stephen Stewart and Ewan ForrestIntroduction 494Alcohol metabolism 494Pathogenesis 496Susceptibility 497Histological features 498Clinical features 501Clinical syndromes 503Prognosis 504Treatment 506Conclusions 507References 50826 Iron Overload States 511<
/> Paul Adams and Heinz ZollerNormal iron physiology 511Iron overload and liver damage  515Genetic haemochromatosis 516Other iron storage diseases 521References 52327 Wilson Disease 526<
/> Eve A. Roberts and Karl Heinz WeissMolecular genetics: pathogenesis 527Pathology 528Clinical picture 529Laboratory tests 532Genetic strategies 533Diagnostic difficulties 533Treatment 533Prognosis 536Non-Wilsonian copper-related cirrhosis 536References 53628 Non‐Alcoholic Fatty Liver Disease 540<
/> Timothy Hardy and Christopher P. DayIntroduction 540Further definitions, terminology, and diagnosis 541Liver biopsy, classification of NAFLD, and non‐ invasive markers of NASH and fi
osis 541 Clinical features 543Laboratory testing 544Epidemiology 545Ethnic variation in NAFLD 545Pathogenesis of NASH 545Natural history of NAFLD 550NAFLD and hepatocellular carcinoma (HCC) 551Therapy for non‐alcoholic fatty liver disease 552Other forms of NAFLD 554References 55529 Nutrition and Chronic Liver Disease 561<
/> Manuela MerliIntroduction 561Epidemiology and general characteristics 562Causes of malnutrition 562Consequences of malnutrition 564Diagnosis and assessment 565Treatment and management 568References 57030 Pregnancy and the Liver 572<
/> Rachel H. West
ook and Catherine WilliamsonIntroduction 572Normal physiology in pregnancy 572Pregnancy‐related liver diseases 573Pre‐existing liver diseases and pregnancy 578Liver transplantation and pregnancy 580Liver disease coincidentallyarising with pregnancy 581Conclusion 582References 58231 The Liver in the Neonate, in Infancy, and Childhood 588<
/> Susan M. Siew and Deirdre A. KellyInvestigation of liver disease in children 588Neonatal jaundice 589Neonatal unconjugated hyperbilirubinaemia 589Neonatal liver disease (conjugated hyperbilirubinaemia) 591Neonatal hepatitis 594Inherited disease in the neonate 596Genetic cholestatic syndromes 598Structural abnormalities: biliary atresia and choledochal cyst 600Acute liver failure in infancy 602Liver disease in older children 605Metabolic disease in older children 607Cirrhosis and portal hypertension 613Liver transplantation 613Tumours of the liver 614References 61532 The Liver in Systemic Diseases 622<
/> James S. Dooley and Christopher McNamaraCollagen‐vascular and autoimmune disorders 622Hepatic granulomas 624Sarcoidosis 626The liver in endocrine disorders 628Amyloidosis 629Porphyrias 632The liver in haemolytic anaemias 634The liver in myelo‐ and lymphoproliferative disease 638Bone marrow transplantation 639Lymphoma 640Extramedullary haemopoiesis 642Rare haematological disorders that may involve the liver 643Lipid storage diseases  643Non‐metastatic complications of malignancy 646References 64633 The Liver in Infections 652<
/> Sanjay Bhagani and Ian CropleyIntroduction 652Jaundice of infections 652Pyogenic liver abscess 652Hepatic amoebiasis 655Tuberculosis of the liver 657Hepatic actinomycosis 659Syphilis of the liver  659Perihepatitis 660Leptospirosis 660Relapsing fever 663Lyme disease 663Rickettsial infections 663Fungal infections 664Schistosomiasis (bilharzia) 665Malaria 667Kala‐azar (visceral leishmaniasis) 668Echinococcosis (hydatid disease) 668Ascariasis 673Strongyloides stercoralis 674Trichinosis 674Toxocara canis (visceral larva migrans) 674Liver flukes  675References 67634 Imaging of the Liver and Diagnostic Approach of Space‐Occupying Lesions 682<
/> Neil H. Davies and Dominic YuUltrasound 682Computed tomography 683Magnetic resonance imaging 685Radioisotope scanning 688Positron emission tomography 691MR spectroscopy 691Conclusions and choice of imaging technique 691References 69135 Benign Liver Tumours 693<
/> Ian R. WanlessDiagnosis of focal liver lesions 693Hepatocellular lesions 693Biliary and cystic lesions 699Mesenchymal tumours 700References 70136 Primary Malignant Neoplasms of the Liver 705<
/> Adam Doyle and Morris ShermanHepatocellular carcinoma 705Intrahepatic cholangiocarcinoma 718Other malignant neoplasms of the liver 721Other sarcomas 722References 72237 Hepatic Transplantation 730 <
/>Lindsay Y. King and Carl L. BergSelection of patients 730Candidates 732Absolute and relative contraindications 737General preparation of the patient 738Donor selection and operation 738The recipient operation 739Immunosuppression 742Postoperative course 743Post‐transplantation complications 744Conclusion 751References 75238 Hepatic Transplantation and HBV, HCV, and HIV Infections 758 <
/>Norah A. TerraultIntroduction 758Hepatitis B and liver transplantation 759Hepatitis C and liver transplantation 763HIV and liver transplantation 770References 773Index 781