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The definitive toxicology text for students and early-career professionals—updated and revised to address new research and methods

For more than 45 years, Casarett and Doull’s Toxicology has set the standard for providing thorough, academic, and authoritative information in clear and engaging ways. Focusing only on what you need to know and written on a level you can easily understand, it provides a concise yet comprehensive look at the science and clinical field of medical toxicology. This new edition builds on the wide success of previous editions, with extensive updates that make the book more clinically relevant to students and beginners in toxicology, pharmacology, pharmacy, and environmental sciences. Chapter-ending self-assessment Q&As and other features make the learning process more effective and efficient.

 

Preface UNIT 1 GENERAL PRINCIPLES OF TOXICOLOGY 1. The Evolving Journey of Toxicology: A Historical Glimpse 2. Principles of Toxicology 3. Mechanisms of Toxicity 4. Risk Assessment UNIT 2 DISPOSITION OF TOXICANTS 5. Absorption, Distribution, and Excretion of Toxicants 6. Biotransformation of Xenobiotics 7. Toxicokinetics UNIT 3 NON-ORGAN-DIRECTED TOXICITY 8. Chemical Carcinogenesis 9. Genetic Toxicology 10. Developmental Toxicology UNIT 4 TARGET ORGAN TOXICITY 11. Toxic Responses of the Blood 12. Toxic Responses of the Immune System 13. Toxic Responses of the Liver 14. Toxic Responses of the Kidney 15. Toxic Responses of the Respiratory System 16. Toxic Responses of the Nervous System 17. Toxic Responses of the Cornea, Retina, and Central Visual System 18. Toxic Responses of the Heart and Vascular System 19. Toxic Responses of the Skin 20. Toxic Responses of the Endocrine System 21. Toxic Responses of the Reproductive System UNIT 5 TOXIC AGENTS 22. Toxic Effects of Pesticides 23. Toxic Effects of Metals 24. Toxic Effects of Solvents and Vapors 25. Toxic Effects of Radiation and Radioactive Materials 26. Toxic Effects of Plants and Animals 27. Food Toxicology: Fundamental and Regulatory Aspects 28. Toxic Effects of Calories 29. Nanoparticle Toxicology UNIT 6 ENVIRONMENTAL TOXICOLOGY 30. Ecotoxicology 31. Air Pollution UNIT 7 APPLICATIONS OF TOXICOLOGY 32. Analytical and Forensic Toxicology 33. Clinical Toxicology 34. Occupational Toxicology Answers to Chapter Questions Index